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RE: Looks like we got ourselves a Convoy

Alberta Since Jan 1, 2021, 0.6% of people with one dose (19,500/3,529,493) were diagnosed with COVID-19 14 days after the first immunization date Since Jan 1, 2021, 3.8% of people with two doses (124,518/3,260,802) were diagnosed with COVID-19 14 days after the second immunization date Since Jan 1, 2021, 1.4% of people with three doses (19,553/1,408,830) were diagnosed with COVID-19 14 days after the third immunization date 57.1% of cases (217,570/381,141) since Jan 1, 2021 were unvaccinated or diagnosed within two weeks from the first dose immunization date 71.9% of hospitalized cases (10,876/15,137) since Jan 1, 2021 were unvaccinated or diagnosed within two weeks from the first dose immunization date 70.6% of COVID-19 deaths (1,403/1,987) since Jan 1, 2021 were unvaccinated or diagnosed within two weeks from the first dose immunization date Fact Check-Alberta government data shows unvaccinated individuals had higher rates of hospitalizations and deaths Hospitalization in Alberta over the last 120 days by vaccination status (See table 6 in Alberta link) 3doses: 58.72/100,000 2doses: 113.54/100,000 No doses: 589.32/100,000
BCSnob 01/28/22 11:00am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

The next next place to look are the websites for various pharmacies in your area that offer vaccinations. Walgreens CVS Etc Or your state health dept https://covid19vaccine.health.ny.gov/ I am still coming up with zero results on finding Comirnaty and am rapidly coming to the conclusion that it isn't available which surely must not be correct. Pfizer/Moderna shots are widely available, so it doesn't seem to be a production issue. Has anyone actually found this product? Can anybody help me find it? Did you see in a previous post that Comirnaty is manufactured by Pfizer? Most websites list vaccines by manufacturer not vaccine name because the vaccine names came out after the websites were made.
BCSnob 01/28/22 10:21am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

I’ve only seen news articles and 2-3 preprints of studies, so far, on Omicron BA.2. What I have seen suggests we should be paying attention to how infections by it progress in other countries. There are hits it may be more infectious than omicron BA.1 (the variant we’re dealing with now).
BCSnob 01/28/22 08:24am Around the Campfire
RE: Looks like we got ourselves a Convoy

Lack of exercise and poor diet are not highly communicable. So what is the R0 for poor diet?
BCSnob 01/28/22 07:44am Around the Campfire
RE: Looks like we got ourselves a Convoy

I understand it's about the mandate. History has proven (smallpox, polio, measles, etc) that vaccination mandates are necessary in order to control highly communicable diseases because there will be those who feel their rights are more important than public safety and financial interests. Outbreaks of highly communicable diseases impact more than just those not vaccinated; there are societal costs dealing with the outbreak (increased healthcare costs for everyone, decreased access to medical resources for those not infected, decreased labor placing increased burdens on employers and healthy employees, increased costs of goods and services for everyone because of decreased labor, etc). If illness in the unvaccinated had no impact on the wider population, then I would not be for a mandate. However, society is not allowed to cast aside those who become infected when it can be prevented (or lessened) with vaccination; we must deal with the consequences of their choice.
BCSnob 01/28/22 06:53am Around the Campfire
RE: Looks like we got ourselves a Convoy

If it is governmental overreach to mandate Covid vaccination is it also overreach for the mandated vaccinations listed here? Or is it vaccination against just Covid that is governmental overreach? State Laws and Mandates by Vaccine Yes.then you better get busy in TX to repeal its 10 mandates for vaccination.
BCSnob 01/28/22 06:29am Around the Campfire
RE: Looks like we got ourselves a Convoy

If it is governmental overreach to mandate Covid vaccination is it also overreach for the mandated vaccinations listed here? Or is it vaccination against just Covid that is governmental overreach? State Laws and Mandates by Vaccine What about mandatory vaccination against rabies for dogs, is that also governmental overreach?
BCSnob 01/28/22 06:24am Around the Campfire
RE: Looks like we got ourselves a Convoy

^^^According to Saskatchewan Government data there is 328 people (120 on account of Covid related issues and 140 of which are incidental) with Covid in Saskatchewan hospitals and 33% of those are not fully vaccinated. click Asymptotic cases of Covid are viral infections and have been proven to cause inflammation in the lungs (based upon ct scans). Would those going into the hospital for other “incidental” reasons needed hospitalization if their body’s were not additionally weakened by a viral infection? They went to the hospital for an incidental reason, were they kept in the hospital for the incidental reason or to be monitored for possible progression of Covid? Based upon the trends in the link from Saskatchewan, that region is still in the growth phase of the Omicron wave. One’s perception of the severity of this wave may change as the wave progresses in your region. We appear to be at or just past the peak in hospitalizations and many of our hospitals (DC metro region) were full because of Covid cases with unvaccinated being a greater percentage than vaccinated.
BCSnob 01/28/22 04:34am Around the Campfire
RE: We're getting ready........for lambing

We still have a couple of weeks before lambs. The forecast, right now, is for us to be on the western edge of the storm and to get <1” of snow.
BCSnob 01/27/22 08:30pm RV Pet Stop
RE: Looks like we got ourselves a Convoy

What will be everyone’s increase in health costs (insurance & taxes) because of the excess hospitalization of those exercising their right to not be vaccinated? What will be the increased deaths (postponed procedures and no beds in an emergency) due to full hospitals from the excess hospitalization s by those exercising their right not to be vaccinated?
BCSnob 01/27/22 04:18pm Around the Campfire
RE: Looks like we got ourselves a Convoy

Delta& Omicron formed in an infected person, one who was most likely not vaccinated. That person’s right to not be vaccinated impacted more than just themselves. So how many of you have advanced degrees in virology, immunology, biology, or some other pertinent field to actually understand the science? I do and I work for a company that is supplying antibody tests for vaccine trials and research on the disease.
BCSnob 01/27/22 03:21pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Here is the computational study I've been waiting for. Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants BioRxiv preprint 25 Jan 2022 The authors studied (by computer modeling) the binding strengths of 100s of theoretical spike sequences (possible mutations) to the ACE2 receptor and determined that 6 of these would provide wide diversity of possible spike sequences with strong binding to ACE2. These 6, if used in combination in a vaccine, would produce the breadth of antibodies and memory cells to protect against all likely SARS-CoV-2 mutations that are capable of infection via binding to ACE2. SARS-CoV-2 has evolved variants within a few years since its emergence. Current vaccines that im641 munize with the WT spike show reduced efficacy for some of these variants, especially the newly emergent Omicron variant. This suggests that vaccines that can protect against multiple variant strains are becoming increasingly important. However, while SARS-CoV-2 is mutable, it is less so than influenza and HIV. Therefore, while universal vaccines against influenza and HIV largely focus on redirecting antibody responses to elicit bnAbs that target conserved regions only, such an approach may not be necessary to protect against SARS-CoV-2 variants. Targeting conserved regions may have disadvantages as well, as antibodies targeting the conserved class 4 RBD epitope can be non-neutralizing (Jette et al. (2021)). In this paper, based on analyses of structures and sequences, we designed antigens that may protect against the most significant antibody-evading variants. Using a neural network, we check that these antigens are viable and can bind ACE2, and so may emerge in the future. We also use a computational model of AM to show that a cocktail of these antigens provides stronger protection against current variants and certain potential variants than the WT vaccination does. In particular, a specific cocktail (sequence 1-6) is predicted to be optimal This idea would be like making a vaccine with wild type, Alpha, Beta, Gamma, Delta, & Omicron; except the 6 theoretical variants selected in this study would have no overlap in their mutations. Taken together, the bulk of our results predict that a specific cocktail of variant antigens used as an immunogen would offer protection against variants of SARS-CoV-2 that may emerge in the future. We hope that experimental efforts to test this prediction will follow. We also suggest one vaccination scheme that may help protect against diverse coronaviruses.
BCSnob 01/27/22 12:42pm Around the Campfire
RE: We're getting ready........for lambing

Meanwhile, Sam and Wendy are enjoying the cold weather. We see them out playing with each other or laying out in the field (either on exposed grass or on the snow). Occasionally, we see them curled up on the hay the sheep have pulled out of the feeder and let fall on the ground (typically when it’s windy). They have the choice to go into the barn (that is where their feeders are); but they choose to be outside. I have seen them carefully walking across the ice.
BCSnob 01/26/22 10:53am RV Pet Stop
RE: Tesla with a generator on a hitch haul

Does CA allow EVs use HOV lanes when there is only 1 person in the vehicle? If so, perhaps the owner chose the Tesla for another reason than their concern for the environment. This might explain why they have no issues with their choice for recharging. My next question is; what is the tow rating of this Tesla? In other words, should this topic be in “Tow Vehicles”?
BCSnob 01/25/22 11:26am Tow Vehicles
RE: We're getting ready........for lambing

We might be going to plan b for vaccinations. We got snow, then rain, then freezing rain, and the the temps dropped below freezing. For the past 2 weekends there has been frozen slush and smooth ice in front of the barn where we vaccinate. It’s too dangerous to bring the sheep into that barn. Plan b is vaccinating right after they deliver. It’s not the ideal method but since it’s a booster for the pregnant ewes it would boost the antibodies in their milk but after the lambs get the colostrum. Delay in boosting is safer than risking a fall and injury on ice for us, the dogs, or the pregnant ewes.
BCSnob 01/22/22 08:19am RV Pet Stop
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Here is another study that detected SARS-CoV-2 in wild white-tailed deer. First detection of SARS-CoV-2 infection in Canadian wildlife identified in free-ranging white-tailed deer (Odocoileus virginianus) from southern Québec, Canada BioRxiv preprint 20 Jan 2022 This quote from the discussion section summarizes the previous studies. The first evidence of SARS-CoV-2 infection in WTD came on the tails of widespread evidence of exposure in this species across the northeastern USA 12. First reported in Iowa 15, followed by evidence from Ohio 14, SARS-CoV-2 infection in WTD appeared to be widespread and has been speculated to have resulted from multiple spillover events from humans. Most recently, evidence of exposure in both captive and free-ranging deer has now been reported in Texas, extending the known geographic range in North America 16,44. In this report, we describe the first detection of SARS-CoV-2 exposure and infection in WTD in Canada. Overall, SARS- CoV-2 was detected in 1.2% (95% CI 0.2–3.6%) of the nasal swabs from sampled deer and neutralizing antibodies against SARS-CoV-2 were detected in 5.6% (95% CI 3.3–9.2%). Notably, the prevalence of infection of SARS-CoV-2 in WTD described in the present study is much lower than what was reported in Iowa (33.2%) and Ohio (35.8%) 14,15. Similarly, our described seroprevalence is substantially lower than the 40% reported for the northeastern USA, or the 37% reported from Texas 12,44. This observation may suggest that spillover of SARS-CoV-2 to WTD in this region of Québec is a recent occurrence. It is not know how wild deer acquired the virus. There is evidence of deer to deer transmission. The current data indicates the infections are in geographic clusters; not yet evenly distributed across all counties or states/provinces. No evidence of deer to human transmission has been found to date. The risk here is white-tailed deer becoming a reservoir of this virus and new variants of concern develop within the deer population.
BCSnob 01/21/22 11:04am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

The next next place to look are the websites for various pharmacies in your area that offer vaccinations. Walgreens CVS Etc Or your state health dept https://covid19vaccine.health.ny.gov/
BCSnob 01/21/22 04:42am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Find COVID-19 Vaccines
BCSnob 01/18/22 02:01pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

There has been some news reports indicating "leaders" are now suggesting we should just let Omicron run its course through the population to help develop "herd immunity". This study was performed in "transgenic mice overexpressing human ACE2 (K18-hACE2)"; mice modified to have analogous responses to SAS-CoV-2 as humans. The key finding in this study was that infection with Delta provided immunity against Omicron; however, infection with Omicron did not provide immunity against Delta. These data suggest that using infection by the milder Omicron (instead of vaccination) as a means to provide population wide immunity against future SARS-CoV-2 variants may not work. The question we should be asking these leaders and the population is, do we want to be part of a population wide experiment to determine if the results in humans match what is found in these mice. Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination MedRxiv preprint 17 Jan 2022 SARS-CoV-2 Delta and Omicron strains are the most globally relevant variants of concern (VOCs). While individuals infected with Delta are at risk to develop severe lung disease, Omicron infection causes less severe disease, mostly upper respiratory symptoms. The question arises whether rampant spread of Omicron could lead to mass immunization, accelerating the end of the pandemic. Here we show that infection with Delta, but not Omicron, induces broad immunity in mice. While sera from Omicron-infected mice only neutralize Omicron, sera from Delta-infected mice are broadly effective against Delta and other VOCs, including Omicron. This is not observed with the WA1 ancestral strain, although both WA1 and Delta elicited a highly pro-inflammatory cytokine response and replicated to similar titers in the respiratory tracts and lungs of infected mice as well as in human airway organoids. Pulmonary viral replication, pro-inflammatory cytokine expression, and overall disease progression are markedly reduced with Omicron infection. Analysis of human sera from Omicron and Delta breakthrough cases reveals effective cross-variant neutralization induced by both viruses in vaccinated individuals. Together, our results indicate that Omicron infection enhances preexisting immunity elicited by vaccines, but on its own may not induce broad, cross-neutralizing humoral immunity in unvaccinated individuals.
BCSnob 01/18/22 07:01am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

....wow. Interesting. I wonder if where the swab is applied to collect the sample for PCR testing is critical.....with Omicron infection detection? ie. Nose? Mouth saliva? Throat? In the NBA study samples from the nostrils and throat were combined for each patient. The data reported here represent a convenience sample including team staff, players, arena staff, and others affiliated with the NBA. The retrospective study includes samples collected between July 5th, 2021, and January 10th, 2022. Clinical samples were obtained by combined swabs of the anterior nares and oropharynx for each patient administered by a trained provider.
BCSnob 01/18/22 06:47am Around the Campfire
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