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RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

My father’s angiogram (and either placement of a stint or scheduling of bypass) was rescheduled and my parents expect it will get pushed again. Meanwhile the nurse who called to reschedule reviewed with my mother the signs of a heart attack. My father gets exhausted going to get the mail from the box. We know someone whose daughter-in-law was taken off life support and died because her lungs were too damaged from Covid-19. She was fully vaccinated but her husband refused to get vaccinated. He got Covid-19 and likely infected her (and other family members).
BCSnob 01/07/22 08:36am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Short answer: No Long answer: ERs in our area are calling surrounding hospitals to send patients to since most have no beds to admit patients from the ER. If current patients or those going to the ERs don’t need hospitalization the ERs would not be trying to admit taking up a bed. We know someone who went in to UMD Medical Center in Baltimore for a surgery (not Covid related) and once she no longer needed ICU care after surgery they had no beds outside of ICU. She was discharged from ICU to a rehab facility. By the end of the day, about 300 more patients had been added to the count, pushing the total above 3,000, said Bob Atlas, president and CEO of the Maryland Hospital Association. That data will not be posted on the state’s coronavirus dashboard until Tuesday morning. By the association’s count, nine of the state’s 44 acute care hospitals have entered crisis mode, including the University of Maryland St. Joseph Medical Center in Towson and Frederick Health Hospital, which adopted the emergency protocols Monday. “Maryland hospitals have been sounding the alarm for the past month — noting that the situation would soon become dire. That has happened,” Atlas said in an email, adding that most hospitals had reached full capacity. “This means that any patient who is not in need of immediate, urgent, emergency care, may have to wait until there is staffing and/or a bed available to treat them.” Maryland hit 3,000 COVID-related hospitalizations Monday, hospital association says Md. state of emergency helps hospitals overwhelmed by COVID-19 patients COVID Hospitalizations top 3,000; Most Md. hospitals at capacity, some in "Crisis" mode Most hospitals in the state are at or near 100% capacity. Nine of the 44 general acute care hospitals are now operating under crisis standards of care. This means that any patient who is not in need of immediate, urgent, emergency care, may have to wait until there is staffing and/or a bed available to treat them. While ERs may have many people seeking care that is less than what requires hospitalization; there are more people in the ERs that do need hospitalization than there are beds in the hospitals. Keep in mind there are ER beds, ICU beds, and in-patient beds in a hospital; in-patient and ICU beds are used for the hospitalization figures. Wait, 2 weeks and we’ll revisit your questions; the start of the omicron wave in NC appears about 2 weeks behind those in FL and MD.
BCSnob 01/06/22 06:59am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

It looks like in FL & NC the rise in the hospitalization curve for the omicron wave is just as steep as it was for the delta wave. It looks steeper for omicron than delta in MD.
BCSnob 01/05/22 07:08pm Around the Campfire
RE: Ins and outs of DNA testing

Like all tools there are the intended uses and the unintended consequences. Examples of unintended consequences for this tool are the elimination of “anonymous” sperm and egg donation and closed adoptions.
BCSnob 12/31/21 03:01pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

There’s trade off between fast turnaround time and high throughput (high volume). You’re right 1 at a time isn’t much; at work I’ve run >5,000 samples at a time. It takes a lot of focus to not screw it up or very expensive automation to run that many samples.
BCSnob 12/30/21 03:39pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel This is from page 31 of the procedure from the cdc on running the real time PCR assay. 16) Before proceeding, the run file must be saved; from the main menu, select File, then Save As. Save in appropriate run folder designation. 17) Load the plate into the plate holder in the instrument. Ensure that the plate is properly aligned in the holder. 18) Once the run file is saved, click the Start button. Note: The run should take approximately 1 hour and 20 minutes to complete. The time is due to the thermal cycling required during the amplification process. This is after quite a lot of prep work getting everything ready. The fastest rtPCR test results (sample collection to test results) I’ve found listed on-line is 2hrs for a clinic that runs the test onsite laboratory for several hundred $. Which PCR test (or testing lab) gave results in ~1hr? Never mind I found Cepheid, Abbott & ThermoFisher have low volume (1 sample at a time) molecular tests (tests for specific pieces of RNA) that provide results in 13-36min.
BCSnob 12/29/21 06:30pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Watch for the numbers on Jan 4 to 6, 2022
BCSnob 12/29/21 08:23am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Novavax has been developing a recombinant protein plus adjuvant vaccine for SARS-CoV-2 which can be shipped refrigerated (not frozen). The WHO recently (20 Dec 2021) gave interim approval for its use. Here is a phase 2 study (small study ~100) of Novavax’s performance against wild type, alpha, beta, delta, and omicron after the initial 2 dose course (14 days) and post booster (28days). The performance was assessed by measuring the ability of the serum to inhibit the binding of ace2 to the pseudo viruses. There was similar reduced inhibition against alpha, beta, and delta and an additional reduction against omicron following the initial 2 doses of vaccine. Boosting increased the inhibition against all variants tested relative to that after the initial 2 doses and there was a smaller difference between the variants. Immunogenicity and Safety Following a Homologous Booster Dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): A Phase 2 Randomized Placebo-Controlled Tria MedRxiv preprint 23 Dec 2021 Now hopefully the FDA will approve the use of this vaccine which only requires refrigeration.
BCSnob 12/25/21 08:22am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

This study from the us military included an evaluation of wild type, alpha, beta, and delta induced natural immunity (previous infection) for the neutralization of wild type, delta, and omicron pseudo viruses. These serum samples were collected 30 days after onset of symptoms (before waning of antibodies). All had reduced neutralization against omicron relative to wild type and delta. This study also includes serum from 2 & 3 doses of Pfizer with the expected performance; boosting required to restore neutralization against omicron. SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster BioRxiv Preprint 22 Dec 2021
BCSnob 12/24/21 01:42pm Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Yes, we’ve been getting the news about increasing rates from various sources. We have a good friend that had surgery at a major hospital in Baltimore. She went from ICU to an external rehab facility because the hospital had no rooms available once she no longer needed ICU care. She stayed in an ICU bed until she was able to be discharged. The safety officer at work told me about the weekly new reports of employees that are under quarantine because of Covid exposures outside of work. For a few days I thought I might be one but our exposure to someone feeling sick; her tests (rapid and PCR) came back negative (the only negative test for the testing location used).
BCSnob 12/24/21 11:24am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

I’m not sure which is more disconcerting, lagging data for Fla or no data for MD (due to a computer failure at md health dept).
BCSnob 12/24/21 09:06am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

No one knew the speed at which the sars-cov-2 spike would mutate when the vaccine manufacture’s started developing their vaccines (immediately after the amino acid sequence was published). There continues to be conserved epitopes (places on the spike where antibodies bind) that are conserved across all sars-cov-2 variants and the other coronaviruses (human and animal). This quote is from the peer reviewed research article that the linked article reviewed which suggests until this research no one knew this portion of the virus was conserved. Cross-reactivity and direct killing of target cells remain underexplored for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+ T cells. Isolation of T cell receptors (TCRs) and overexpression in allogeneic cells allows for extensive T cell reactivity profiling. We identify SARS-CoV-2 RNA-dependent RNA polymerase (RdRp/NSP12) as highly conserved, likely due to its critical role in the virus life cycle. Cell Reports
BCSnob 12/24/21 08:10am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Both guys were triple-vaxxed; Cramer had tested negative shortly before a gathering that both men had attended that required PCR tests; and the next day realized he had Covid and tested positive and that Carl had been infected (and apparently Cramer's wife, too) I wonder if they quarantined after taking their tests or did they continue their normal routines and have a potential exposure after taking their tests.
BCSnob 12/23/21 10:20am Around the Campfire
RE: COVID PERSONAL EXPERIENCES

I saw this. Based upon apparent waning antibody levels, the poor protection against Omicron by Pfizer’s vaccine, and the lack of politicization of combating Covid-19 in Israel it makes sense they would roll out another round of vaccinations. Higher antibody levels can help offset the poorer protection against Omicron.
BCSnob 12/22/21 10:31am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

PCR tests generally have very low false positive results (specificity) but can suffer from false negative (sensitivity) tests early in the course of the disease. The patients can be categorized as SARS-CoV-2 positive (active case) or SARS-CoV-2 negative based on the outcome of the RT-PCR results. However, this technique does not give information for the patients who have already recovered from the SARS-CoV-2, since the viral load is cleared out of the body after recovery. Equally, the patients who are in the very first days of the viral infection may not respond “positive” with this test due to the inadequate amount of the virus on the swabs. COVID-19 diagnosis —A review of current methods Biosens Bioelectron. 2021 Jan 15; 172: 112752. How many times have we seen news articles where tested negative airline passengers ended up testing positive upon arrival? Isn't this the scenario for several of the first identified Omicron cases outside of South Africa? It sounds like these on air personalities got a lesson in diagnostic sensitivity and specificity; and in the practicality of mask use even for those vaccinated and/or tested.
BCSnob 12/21/21 09:32am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Here is more info on Moderna's performance against several variants. Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants SCIENCE 13 Aug 2021 Vol 373, Issue 6561 pp. 1372-1377 side note: MSD-ECLIA are products we (the biotech co I work for) make in association with the NIH/NIAID/VRC (sorry, more acronyms). ECLIA; electrochemiluminescence immunoassay NIH: National Institute of Health NIAID: National Institute of Allergy and Infectious Diseases VRC: Vaccine Research Center
BCSnob 12/20/21 11:52am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Variants of concern CDC. WHO Current VOCs Alpha Beta Gamma Delta Omicron
BCSnob 12/20/21 11:31am Around the Campfire
RE: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

Keep in mind that the serum samples for those vaccinated with Moderna and Pfizer were purposely chosen based upon having high antibody titers; meaning patients that responded well to the vaccines and were likely recently vaccinated. Based upon the above I wouldn’t characterize 2 doses of Moderna as impressive; there was still a reduction in neutralization of Omicron relative to the wild type (larger reduction than there was for Delta relative to the wild type, it was 2x-3x for serum collected 1 week post 2nd dose link). I would characterize 2 doses of Moderna as less concerning as 2 doses of Pfizer. However, it is Moderna (relative to Pfizer) responses to VOCs that lead to my decision to stick with Moderna for my booster. The preprint (full pdf) discusses results listed in supplemental tables which were not present in the initial posting.
BCSnob 12/20/21 09:16am Around the Campfire
RE: Stop using AIOW please!

I doubt there is anyone here who doesn’t use language shortcuts (abbreviations, acronyms, jargon, etc).
BCSnob 12/19/21 10:52am General RVing Issues
RE: Stop using AIOW please!

Question? Had the amount of acronyms here even come close to the amount used and has been used for decades in the military?
BCSnob 12/18/21 06:03pm General RVing Issues
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