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Open Roads Forum  >  RV Pet Stop  >  Dogs

 > Nexgard or Bravecto chewable flea and tick protection

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colliehauler

Mc Pherson KS USA

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Posted: 05/19/16 11:48am Link  |  Quote  |  Print  |  Notify Moderator

BCSnob wrote:

I did a google search on +MDR1 (name of mutation for "ivermectin sensitivity") and each of the drug names (+fluralaner and +afoxolaner); the "+" requires these terms to be found in the websites.


Safety of fluralaner (Bravecto), a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration
Walther FM, Paul AJ, Allan MJ, Roepke RK, Nuernberger MC.
Parasit Vectors. 2014 Mar 6;7:86. doi: 10.1186/1756-3305-7-86.

Abstract

BACKGROUND:
Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies.

METHODS:
Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Eight Collies received fluralaner chewable tablets once at a dose of 168 mg/kg; eight sham dosed Collies served as controls. All Collies were clinically observed until 28 days following treatment.

RESULTS:
No adverse events were observed subsequent to fluralaner treatment of MDR1(-/-) Collies at three times the highest expected clinical dose.

CONCLUSIONS:
Fluralaner chewable tablets are well tolerated in MDR1(-/-) Collies following oral administration.




CVMP assessment report for NexGard
Pharmacokinetics
The applicant provided pharmacokinetic studies following oral administration in dogs.
Afoxolaner is rapidly absorbed from the gastrointestinal tract. In dogs administered doses varying from 1 to 4 mg/kg bw, Tmax ranged from 2 to 12 hours; the mean Cmax ranged from 538 (1 mg/kg bw) to 2,147 ng/ml (4 mg/kg bw); the mean half-life ranged from 7.7 to 17.8 days; and, the mean AUCinf ranged from 7225 (1.0 mg/kg bw) to 30,107 day?ng/ml (4.0 mg/kg bw). After oral administration of 2.5 mg afoxolaner/kg bw bioavailability was calculated to be approximately 74%.
For the pivotal pharmacokinetic parameters, there was no significant difference between the fed and fasted state.
While a dose-dependent increase was seen for AUCinf and Cmax at doses up to 40 mg/kg bw, maximum plasma concentrations increased less than proportionally at higher doses (100 mg/kg bw and more). The dose proportionality is limited for afoxolaner due to solubility limited absorption.

In ivermectin sensitive Collies, Cmax was markedly higher at a dose of 25 mg/kg bw compared to studies using Beagles receiving 20 mg/kg bw, 14,000 ± 4,000 ng/ml and 7,690 ± 1,920 ng/ml respectively. Also, afoxolaner appeared to have a longer half-life in Collies (mean of 33 days at a dose of 25 mg/kg bw) than in Beagles. However, there were no serious adverse events observed following the dose of 25 mg/kg bw (i.e. 10x the therapeutic dose) administered to Collie dogs. Using the longest half-life of 47.7 days, and the maximum exposure dose (following recommended use) of 6.3 mg/kg bw, the highest steady state afoxolaner plasma concentrations predicted in Collie dogs would not exceed the maximum exposure (100 mg/kg bw and higher) achieved in toxicology studies in the target animal.
Thanks for doing the research and all that typing. It is appreciated. Sounds like its safe for my Collies.

colliehauler

Mc Pherson KS USA

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Posted: 05/19/16 11:54am Link  |  Quote  |  Print  |  Notify Moderator

I wanted to say thank you for all that took the time to respond. Sounds like its safe for my Collies. Vet has the Bravecto for $53. A dose but it's good for three months.

Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 05/19/16 05:51pm Link  |  Quote  |  Print  |  Notify Moderator

colliehauler wrote:

I wanted to say thank you for all that took the time to respond. Sounds like its safe for my Collies. Vet has the Bravecto for $53. A dose but it's good for three months.


I think I paid $52/dose last year, so that seems about right. And to NOT have 2 dogs in bed with us, scratching half the night?? Priceless ;-)

Winged One

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Posted: 05/22/16 04:48pm Link  |  Quote  |  Print  |  Notify Moderator

We looked at both for our Great Pyrenees this last month. She is allergic to the liquid applied to the body.

The problem with Bravecto, it is a once/3 months dosage that only protects against lone star ticks for 2 months. As we travel into areas with those ticks, having her unprotected for a month before the next dosage was unacceptable to us.

I find it unfathomable, that they would create a treatment that leaves such large gaps in protection.

So we went with the more expensive Nexgard. For the last 2 years, it has worked very well for her.


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DustyR

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Posted: 05/22/16 06:21pm Link  |  Quote  |  Print  |  Notify Moderator

mockturtle wrote:

My 14-year old half-Lhasa has been using Bravecto for almost two years with no ill effects and it is highly effective for both fleas and ticks.


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BCSnob

Middletown, MD

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Posted: 05/22/16 06:28pm Link  |  Quote  |  Print  |  Notify Moderator

Frontline still works for us; unfortunately it's been consistently too wet to treat our Maremma Sheepdog. Our Border Collies have been treated.

* This post was edited 05/23/16 04:32am by BCSnob *

campn4walleye

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Posted: 05/31/16 08:12pm Link  |  Quote  |  Print  |  Notify Moderator

RBak wrote:

Better check with your vet before you try any of these. Collies and Shelties can be sensitive to certain chemical ingredients - I've used Frontline Plus for many years with good results, and my present sheltie Buttons has a "show coat" - very thick, but so far no sign of fleas or tick. We were in Colorado 2 weeks ago hiking on the trails and I'm sure there were ticks and other critters, but Buttons had no living souvenirs from our trip. Best wishes to you and all the collies.

Rita
Buttons the princess sheltie
Nicky the spoiled Tennessee Walker


We lived in WY and our vet told us that ticks and fleas cannot live in high altitudes. Our boy never had a tick but got fleas when visitors came from the East coast and brought some. (We quickly found out he was highly allergic).


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Posted: 04/15/22 05:00am Link  |  Quote  |  Print  |  Notify Moderator

No one is more protective of their fur babies than we are. We were using Advantix on our small dog. Suddenly she started having fleas and that was within one week of me applying the Advantix. Since the bites were causing dermatitis our vet suggested Bravecto. She has no ill side effects from it. Our large dog still uses Frontline and it still works for him. He cannot use any type of pill for fleas since he had idiopathic seizures.
The only thing I do different is during the cold winter months when we are home and not travelling I will put Advantix on Lucie and give her body a break from the pill. This works well and the vet does not have a problem with us doing that. We have not seen a flea on her since the Bravecto.


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alicelay56

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Posted: 05/16/22 10:34pm Link  |  Quote  |  Print  |  Notify Moderator

Thanks for sharing valuable information with us. It is pivotal to know what our furr prescribed. And I'm glad to know this, Bravecto for dogs is safe to use. Someone recommended this product when my dog is affected by flea and ticks. I research a lot about this and bought it from https://www.petcaresupplies.com/bravecto-for-dogs/flea-and-tick-control-treatment-317.aspx at a reasonable price. After using this, my pal is healthy and happy. I love this product. Great job!

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