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 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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charlestonsouthern

Summerville, SC

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Posted: 08/27/21 12:56pm Link  |  Quote  |  Print  |  Notify Moderator

I'm looking and listening to hear more about the booster shots! Dr. Fauci has indicated an approximate date of September 20, 2021 for introduction first to those who have an autoimmune problem. Does anyone else have additional sourced information?

BCSnob

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Posted: 08/27/21 01:03pm Link  |  Quote  |  Print  |  Notify Moderator

FDA NEWS RELEASE

Coronavirus (COVID-19) Update: FDA Authorizes Additional Vaccine Dose for Certain Immunocompromised Individuals

Aug 12, 2021

Based upon this announcement, immunocompromised patients can get their Pfizer or Moderna booster now.

Pawz4me

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Posted: 08/27/21 01:47pm Link  |  Quote  |  Print  |  Notify Moderator

charlestonsouthern wrote:

I'm looking and listening to hear more about the booster shots! Dr. Fauci has indicated an approximate date of September 20, 2021 for introduction first to those who have an autoimmune problem. Does anyone else have additional sourced information?


Third doses for certain immune compromised/immune suppressed people have already been authorized. I had my third dose on 8/16. Here's the CDC info.


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BCSnob

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Posted: 08/27/21 04:35pm Link  |  Quote  |  Print  |  Notify Moderator

Serious adverse reactions to the AstraZeneca and Pfizer covid vaccines are also caused by covid-19 infection. The risk of these adverse reactions were found to be significantly higher due to the infection than due to the vaccine.

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study
British Medical Journal

Quote:

Conclusion Increased risks of haematological and vascular events that led to hospital admission or death were observed for short time intervals after first doses of the ChAdOx1 nCoV-19 and BNT162b2 mRNA vaccines. The risks of most of these events were substantially higher and more prolonged after SARS-CoV-2 infection than after vaccination in the same population.


dturm

Lake County, IN

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Posted: 08/28/21 07:23am Link  |  Quote  |  Print  |  Notify Moderator

Ivermectin has been in the news recently and real accurate information about this drug should be shared. Most people who follow this thread probably are not considering Ivermectin as a treatment but probably do have friends or family members who are. As a veterinarian, I have prescribed and used this drug more than any other since the mid 80s. Below is a information from the NIH and CDC.

NIH
CDC

The most important take away is:

NIH wrote:

Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures. However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.


In the real world, we primarily use Ivermectin in my branch of veterinary medicine as a heartworm preventive dosed at 6-12 mcg /kg (that’s micrograms NOT milligrams) once a month. At this dosage level this drug is extremely safe for dogs and yet there are some (very, very few) minor reactions. It is also used at 10X (or more) dose more frequent dosage (daily) for some ectoparasite problems (mange). This drug becomes problematic for many individuals at this level and is contraindicated for those specifically with a ABCB1 (formerly MDR1) mutation found frequently in collie related breeds. THIS MUTATION IS ALSO FOUND IN PEOPLE. The most common serious reactions have to do with neurological issues leading to seizures in susceptible individuals.

Similar adverse reactions have been reported in all species we treat, horses, cattle, sheep, rodents and birds, reptiles and probably others I’m not aware of.

The major compounding issue using animal drugs is the dosage calculations. One has to convert the dose micrograms per kg to pounds, to milligrams, to the animal strength (1% in the cattle version) to the milliliter liquid dose. I do this calculation frequently and always double check and have someone check my work. People not familiar with these values and the math are prone to making mistakes, and with the concentrations of these medications MISTAKES ARE SERIOUS.

Also of interest is the interaction of concurrent use of other medications with Ivermectin, specifically statins, warfarin, calcium channel blockers. Do a search about calls to poison control centers about ivermectin and you will get multiple hits from many states with recent astronomical increases in calls.

Contrary to “news” talking heads and internet sites, this drug is not innocuous. It should only be used under the supervision of YOUR doctor that knows your history and concurrent medication history, and frankly until there is conclusive evidence that it actually safely works to prevent or treat COVID, there are better, safer and approved treatment and preventives.


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Deb and Ed M

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Posted: 08/28/21 07:53am Link  |  Quote  |  Print  |  Notify Moderator

Thanks for that info, Dr Doug - at least it explains why so many folks are suddenly on the ivermectin bandwagon. The "leap" from cell cultures to "humans" is a pretty big jump, IMO; yet people seem willing to try it (hence the calls to Poison Control) rather than simply getting vaccinated.

dturm

Lake County, IN

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Posted: 08/29/21 05:08am Link  |  Quote  |  Print  |  Notify Moderator

Definition of Vaccine from Wikipedia
https://en.wikipedia.org/wiki/Vaccine

Quote:

A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylactic (to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (to fight a disease that has already occurred, such as cancer). Some vaccines offer full sterlizing immunity, in which infection is prevented completely.


* This post was edited 08/29/21 08:26am by dturm *

azdryheat

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Posted: 08/29/21 09:27am Link  |  Quote  |  Print  |  Notify Moderator

Wikipedia definition needs to be updated.
From the CDC:

"New Approach to Vaccines

mRNA vaccines are a new type of vaccine to protect against infectious diseases. To trigger an immune response, many vaccines put a weakened or inactivated germ into our bodies. Not mRNA vaccines. Instead, they teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. That immune response, which produces antibodies, is what protects us from getting infected if the real virus enters our bodies."


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BCSnob

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Posted: 08/29/21 11:04am Link  |  Quote  |  Print  |  Notify Moderator

Unfortunately, the data on the efficacy of ivermectin has been tainted by issues with one of the largest studies posted as a preprint.

Large Ivermectin Study Retracted

This is not to say there hasn’t been smaller studies with promising results; just that there hasn’t been a well designed large study published. I’m getting the same feeling about the social media hype and published studies on ivermectin as I did for hydroxychloroquine (more promise in social media than supported by data, at this time).




There is another published article which is under review by the editors of the journal.

The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
The Journal of Antibiotics(2021) 15 June 2021
Quote:

22 June 2021 Editor’s Note: Readers are alerted that the conclusions of this paper are subject to criticisms that are being considered by the editors and the publisher. A further editorial response will follow the resolution of these issues.



Unfortunately, these studies (retracted or under editorial review) are being included in reviews of the effectiveness of treating COVID-19 with ivermectin.

* This post was last edited 08/30/21 07:46am by BCSnob *   View edit history

BCSnob

Middletown, MD

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Posted: 08/30/21 07:26am Link  |  Quote  |  Print  |  Notify Moderator

Here is a recently published literature review article that compiled and evaluated all of the publish randomized clinical trials using ivermectin to treat or prevent Covid-19. I have quoted the full summary for everyone to review.

Ivermectin for preventing and treating COVID-19
Cochrane Database of Systematic Reviews
Version published: 28 July 2021

Quote:


Main results

We found 14 studies with 1678 participants investigating ivermectin compared to no treatment, placebo, or standard of care. No study compared ivermectin to an intervention with proven efficacy. There were nine studies treating participants with moderate COVID-19 in inpatient settings and four treating mild COVID-19 cases in outpatient settings. One study investigated ivermectin for prevention of SARS-CoV-2 infection. Eight studies had an open-label design, six were double-blind and placebo-controlled. Of the 41 study results contributed by included studies, about one third were at overall high risk of bias.

Ivermectin doses and treatment duration varied among included studies.

We identified 31 ongoing and 18 studies awaiting classification until publication of results or clarification of inconsistencies.

Ivermectin compared to placebo or standard of care for inpatient COVID-19 treatment

We are uncertain whether ivermectin compared to placebo or standard of care reduces or increases mortality (risk ratio (RR) 0.60, 95% confidence interval (CI) 0.14 to 2.51; 2 studies, 185 participants; very low-certainty evidence) and clinical worsening up to day 28 assessed as need for invasive mechanical ventilation (IMV) (RR 0.55, 95% CI 0.11 to 2.59; 2 studies, 185 participants; very low-certainty evidence) or need for supplemental oxygen (0 participants required supplemental oxygen; 1 study, 45 participants; very low-certainty evidence), adverse events within 28 days (RR 1.21, 95% CI 0.50 to 2.97; 1 study, 152 participants; very low-certainty evidence), and viral clearance at day seven (RR 1.82, 95% CI 0.51 to 6.48; 2 studies, 159 participants; very low-certainty evidence). Ivermectin may have little or no effect compared to placebo or standard of care on clinical improvement up to 28 days (RR 1.03, 95% CI 0.78 to 1.35; 1 study; 73 participants; low-certainty evidence) and duration of hospitalization (mean difference (MD) -0.10 days, 95% CI -2.43 to 2.23; 1 study; 45 participants; low-certainty evidence). No study reported quality of life up to 28 days.

Ivermectin compared to placebo or standard of care for outpatient COVID-19 treatment

We are uncertain whether ivermectin compared to placebo or standard of care reduces or increases mortality up to 28 days (RR 0.33, 95% CI 0.01 to 8.05; 2 studies, 422 participants; very low-certainty evidence) and clinical worsening up to 14 days assessed as need for IMV (RR 2.97, 95% CI 0.12 to 72.47; 1 study, 398 participants; very low-certainty evidence) or non-IMV or high flow oxygen requirement (0 participants required non-IMV or high flow; 1 study, 398 participants; very low-certainty evidence). We are uncertain whether ivermectin compared to placebo reduces or increases viral clearance at seven days (RR 3.00, 95% CI 0.13 to 67.06; 1 study, 24 participants; low-certainty evidence). Ivermectin may have little or no effect compared to placebo or standard of care on the number of participants with symptoms resolved up to 14 days (RR 1.04, 95% CI 0.89 to 1.21; 1 study, 398 participants; low-certainty evidence) and adverse events within 28 days (RR 0.95, 95% CI 0.86 to 1.05; 2 studies, 422 participants; low-certainty evidence). None of the studies reporting duration of symptoms were eligible for primary analysis. No study reported hospital admission or quality of life up to 14 days.

Ivermectin compared to no treatment for prevention of SARS-CoV-2 infection

We found one study. Mortality up to 28 days was the only outcome eligible for primary analysis. We are uncertain whether ivermectin reduces or increases mortality compared to no treatment (0 participants died; 1 study, 304 participants; very low-certainty evidence). The study reported results for development of COVID-19 symptoms and adverse events up to 14 days that were included in a secondary analysis due to high risk of bias. No study reported SARS-CoV-2 infection, hospital admission, and quality of life up to 14 days.


Authors' conclusions

Based on the current very low- to low-certainty evidence, we are uncertain about the efficacy and safety of ivermectin used to treat or prevent COVID-19. The completed studies are small and few are considered high quality. Several studies are underway that may produce clearer answers in review updates. Overall, the reliable evidence available does not support the use of ivermectin for treatment or prevention of COVID-19 outside of well-designed randomized trials.


Sorry mod I can’t help myself

Don’t be a sheeple and self medicate with a sheep dewormer!

* This post was edited 08/30/21 08:00am by BCSnob *

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