Good Sam Club Open Roads Forum: Around the Campfire: 2019–2022 CORONAVIRUS PANDEMIC POSTINGS
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 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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silversand

Montreal

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Joined: 09/12/2004

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Posted: 01/16/22 08:57am Link  |  Quote  |  Print  |  Notify Moderator

Thanks BC Snob ! I am now starting the read.

BC Snob wrote:

(see study from NBA samples) suggests that patients with Omicron could be infectious a day or two after exposure to an infectious person and before the onset of symptoms or PCR positive test.


....wow. Interesting. I wonder if where the swab is applied to collect the sample for PCR testing is critical.....with Omicron infection detection? ie. Nose? Mouth saliva? Throat?

* This post was edited 01/16/22 09:13am by silversand *


Silver
2004 Chevy Silverado 2500HD 4x4 6.0L Ext/LB Tow Package 4L80E Michelin AT2s| Outfitter Caribou

BCSnob

Middletown, MD

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Joined: 02/23/2002

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Posted: 01/18/22 06:47am Link  |  Quote  |  Print  |  Notify Moderator

silversand wrote:

....wow. Interesting. I wonder if where the swab is applied to collect the sample for PCR testing is critical.....with Omicron infection detection? ie. Nose? Mouth saliva? Throat?

In the NBA study samples from the nostrils and throat were combined for each patient.
Quote:

The data reported here represent a convenience sample including team staff, players, arena staff, and others affiliated with the NBA. The retrospective study includes samples collected between July 5th, 2021, and January 10th, 2022. Clinical samples were obtained by combined swabs of the anterior nares and oropharynx for each patient administered by a trained provider.


BCSnob

Middletown, MD

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Posted: 01/18/22 07:01am Link  |  Quote  |  Print  |  Notify Moderator

There has been some news reports indicating "leaders" are now suggesting we should just let Omicron run its course through the population to help develop "herd immunity".

This study was performed in "transgenic mice overexpressing human ACE2 (K18-hACE2)"; mice modified to have analogous responses to SAS-CoV-2 as humans. The key finding in this study was that infection with Delta provided immunity against Omicron; however, infection with Omicron did not provide immunity against Delta. These data suggest that using infection by the milder Omicron (instead of vaccination) as a means to provide population wide immunity against future SARS-CoV-2 variants may not work.

The question we should be asking these leaders and the population is, do we want to be part of a population wide experiment to determine if the results in humans match what is found in these mice.

Quote:

Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination
MedRxiv preprint 17 Jan 2022

SARS-CoV-2 Delta and Omicron strains are the most globally relevant variants of concern (VOCs). While individuals infected with Delta are at risk to develop severe lung disease, Omicron infection causes less severe disease, mostly upper respiratory symptoms. The question arises whether rampant spread of Omicron could lead to mass immunization, accelerating the end of the pandemic. Here we show that infection with Delta, but not Omicron, induces broad immunity in mice. While sera from Omicron-infected mice only neutralize Omicron, sera from Delta-infected mice are broadly effective against Delta and other VOCs, including Omicron. This is not observed with the WA1 ancestral strain, although both WA1 and Delta elicited a highly pro-inflammatory cytokine response and replicated to similar titers in the respiratory tracts and lungs of infected mice as well as in human airway organoids. Pulmonary viral replication, pro-inflammatory cytokine expression, and overall disease progression are markedly reduced with Omicron infection. Analysis of human sera from Omicron and Delta breakthrough cases reveals effective cross-variant neutralization induced by both viruses in vaccinated individuals. Together, our results indicate that Omicron infection enhances preexisting immunity elicited by vaccines, but on its own may not induce broad, cross-neutralizing humoral immunity in unvaccinated individuals.


PDQXYZ

NY

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Posted: 01/18/22 11:34am Link  |  Quote  |  Print  |  Notify Moderator

My employer says I must get a shot, so I would like to get the one that is FDA approved. Having trouble finding it around here. Can you folks tell me where I could get it?

Boon Docker

Mountain Foothills of Southern Alberta

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Posted: 01/18/22 01:36pm Link  |  Quote  |  Print  |  Notify Moderator

PDQXYZ wrote:

My employer says I must get a shot, so I would like to get the one that is FDA approved. Having trouble finding it around here. Can you folks tell me where I could get it?


Pfizer-BioNTech COVID-19 Vaccine also known as "Comirnaty"

BCSnob

Middletown, MD

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Posted: 01/18/22 02:01pm Link  |  Quote  |  Print  |  Notify Moderator

Find COVID-19 Vaccines

PDQXYZ

NY

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Posted: 01/18/22 02:25pm Link  |  Quote  |  Print  |  Notify Moderator

Yeah, comirnaty that is the one I want.

liamricci

Texas

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Posted: 01/19/22 02:19pm Link  |  Quote  |  Print  |  Notify Moderator

Boon Docker wrote:

PDQXYZ wrote:

My employer says I must get a shot, so I would like to get the one that is FDA approved. Having trouble finding it around here. Can you folks tell me where I could get it?


Pfizer-BioNTech COVID-19 Vaccine also known as "Comirnaty"

Is that the only one FDA approved. What about Moderna and others?
In any case i think vaccination is essential but still not everything. We should all remember to wear masks properly, disinfect our hands and take vitamins from canada drugs to boost our immune system.

* This post was edited 01/30/22 01:31pm by liamricci *

Boon Docker

Mountain Foothills of Southern Alberta

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Posted: 01/19/22 06:10pm Link  |  Quote  |  Print  |  Notify Moderator

liamricci wrote:

Boon Docker wrote:

PDQXYZ wrote:

My employer says I must get a shot, so I would like to get the one that is FDA approved. Having trouble finding it around here. Can you folks tell me where I could get it?


Pfizer-BioNTech COVID-19 Vaccine also known as "Comirnaty"

Is that the only one FDA approved. What about Moderna and others?


Pretty sure Comirnaty is the only one approved at the present time.

Moderator

Tennessee

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Posted: 01/19/22 06:16pm Link  |  Quote  |  Print  |  Notify Moderator

Approved Vaccines ( right column )

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