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 > 2019–2022 CORONAVIRUS PANDEMIC POSTINGS

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nickthehunter

Southgate, MI

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Posted: 01/20/22 11:01am Link  |  Quote  |  Print  |  Notify Moderator

There is a difference between being "Approved" and being "Approved for Emergency Use"

PDQXYZ

NY

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Posted: 01/21/22 04:37am Link  |  Quote  |  Print  |  Notify Moderator

BCSnob wrote:

***Link Removed***


I had been there before, none of the places listed has Comirnaty, just the other versions.

BCSnob

Middletown, MD

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Posted: 01/21/22 04:42am Link  |  Quote  |  Print  |  Notify Moderator

The next next place to look are the websites for various pharmacies in your area that offer vaccinations.
Walgreens
CVS
Etc

Or your state health dept
https://covid19vaccine.health.ny.gov/

BCSnob

Middletown, MD

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Posted: 01/21/22 11:04am Link  |  Quote  |  Print  |  Notify Moderator

Here is another study that detected SARS-CoV-2 in wild white-tailed deer.

First detection of SARS-CoV-2 infection in Canadian wildlife identified in free-ranging white-tailed deer (Odocoileus virginianus) from southern Québec, Canada
BioRxiv preprint 20 Jan 2022

This quote from the discussion section summarizes the previous studies.

Quote:

The first evidence of SARS-CoV-2 infection in WTD came on the tails of widespread evidence of exposure in this species across the northeastern USA 12. First reported in Iowa 15, followed by evidence from Ohio 14, SARS-CoV-2 infection in WTD appeared to be widespread and has been speculated to have resulted from multiple spillover events from humans. Most recently, evidence of exposure in both captive and free-ranging deer has now been reported in Texas, extending the known geographic range in North America 16,44. In this report, we describe the first detection of SARS-CoV-2 exposure and infection in WTD in Canada. Overall, SARS- CoV-2 was detected in 1.2% (95% CI 0.2–3.6%) of the nasal swabs from sampled deer and neutralizing antibodies against SARS-CoV-2 were detected in 5.6% (95% CI 3.3–9.2%). Notably, the prevalence of infection of SARS-CoV-2 in WTD described in the present study is much lower than what was reported in Iowa (33.2%) and Ohio (35.8%) 14,15. Similarly, our described seroprevalence is substantially lower than the 40% reported for the northeastern USA, or the 37% reported from Texas 12,44. This observation may suggest that spillover of SARS-CoV-2 to WTD in this region of Québec is a recent occurrence.


It is not know how wild deer acquired the virus. There is evidence of deer to deer transmission. The current data indicates the infections are in geographic clusters; not yet evenly distributed across all counties or states/provinces. No evidence of deer to human transmission has been found to date.

The risk here is white-tailed deer becoming a reservoir of this virus and new variants of concern develop within the deer population.

* This post was edited 01/21/22 11:16am by BCSnob *

BCSnob

Middletown, MD

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Posted: 01/27/22 12:42pm Link  |  Quote  |  Print  |  Notify Moderator

Here is the computational study I've been waiting for.

Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants
BioRxiv preprint 25 Jan 2022

The authors studied (by computer modeling) the binding strengths of 100s of theoretical spike sequences (possible mutations) to the ACE2 receptor and determined that 6 of these would provide wide diversity of possible spike sequences with strong binding to ACE2. These 6, if used in combination in a vaccine, would produce the breadth of antibodies and memory cells to protect against all likely SARS-CoV-2 mutations that are capable of infection via binding to ACE2.

Quote:

SARS-CoV-2 has evolved variants within a few years since its emergence. Current vaccines that im641 munize with the WT spike show reduced efficacy for some of these variants, especially the newly
emergent Omicron variant. This suggests that vaccines that can protect against multiple variant strains are becoming increasingly important. However, while SARS-CoV-2 is mutable, it is less so than influenza and HIV. Therefore, while universal vaccines against influenza and HIV largely focus on redirecting antibody responses to elicit bnAbs that target conserved regions only, such an approach may not be necessary to protect against SARS-CoV-2 variants. Targeting conserved regions may have disadvantages as well, as antibodies targeting the conserved class 4 RBD epitope can be non-neutralizing (Jette et al. (2021)). In this paper, based on analyses of structures and sequences, we designed antigens that may protect against the most significant antibody-evading variants. Using a neural network, we check that these antigens are viable and can bind ACE2, and so may emerge in the future. We also use a computational model of AM to show that a cocktail of these antigens provides stronger protection against current variants and certain potential variants than the WT vaccination does. In particular, a specific cocktail (sequence 1-6) is predicted to be optimal


This idea would be like making a vaccine with wild type, Alpha, Beta, Gamma, Delta, & Omicron; except the 6 theoretical variants selected in this study would have no overlap in their mutations.

Quote:

Taken together, the bulk of our results predict that a specific cocktail of variant antigens used as an immunogen would offer protection against variants of SARS-CoV-2 that may emerge in the future. We hope that experimental efforts to test this prediction will follow. We also suggest one vaccination scheme that may help protect against diverse coronaviruses.


Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 01/27/22 07:32pm Link  |  Quote  |  Print  |  Notify Moderator

That sounds wonderful!!

BCSnob

Middletown, MD

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Posted: 01/28/22 08:24am Link  |  Quote  |  Print  |  Notify Moderator

I’ve only seen news articles and 2-3 preprints of studies, so far, on Omicron BA.2. What I have seen suggests we should be paying attention to how infections by it progress in other countries. There are hits it may be more infectious than omicron BA.1 (the variant we’re dealing with now).

PDQXYZ

NY

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Posted: 01/28/22 09:01am Link  |  Quote  |  Print  |  Notify Moderator

BCSnob wrote:

The next next place to look are the websites for various pharmacies in your area that offer vaccinations.
Walgreens
CVS
Etc

Or your state health dept
https://covid19vaccine.health.ny.gov/


I am still coming up with zero results on finding Comirnaty and am rapidly coming to the conclusion that it isn't available which surely must not be correct. Pfizer/Moderna shots are widely available, so it doesn't seem to be a production issue.

Has anyone actually found this product? Can anybody help me find it?

Deb and Ed M

SW MI & Space Coast, FL USA

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Posted: 01/28/22 09:19am Link  |  Quote  |  Print  |  Notify Moderator

BCSnob wrote:

I’ve only seen news articles and 2-3 preprints of studies, so far, on Omicron BA.2. What I have seen suggests we should be paying attention to how infections by it progress in other countries. There are hits it may be more infectious than omicron BA.1 (the variant we’re dealing with now).


The news this morning mentioned this - but breezily passed it off as something that was happening in Europe. At the risk of being cynical, I figure that means it's well-entrenched in the USA and about to explode. And in spite of what Florida's proposed new Health Director says about "masks not helping" - I WILL be wearing masks and social distancing when in public

MEXICOWANDERER

las peñas, michoacan, mexico

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Posted: 01/28/22 10:08am Link  |  Quote  |  Print  |  Notify Moderator

Comparing the two messenger vaccines

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